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Biosynthetic pathways of vanillin, vanillyl Liquor and vanillic acid production from veratraldehyde.coli K-12 MG1655 that knocking out a few genes encoding aldo-keto reductases and 3 genes encoding Liquor dehydrogenases was received [34]. By reworking the de novo artificial pathway into this pressure, 119 mg/L vanillin was produced from glucose. R